Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder

Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder

We previously demonstrated that prenatal exposure to valproic acid (VPA), an environmental model of autism spectrum disorder (ASD), leads to a hyperexcitable phenotype associated with downregulation of inward-rectifying potassium currents in nucleus accumbens (NAc) medium spiny neurons (MSNs) of ado...

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Bibliographic Details
Main Authors: D. Iezzi, L. Curti, G. Ranieri, E. Gerace, A. Costa, A. Ilari, A. La Rocca, C. Luceri, M. D’Ambrosio, L. Silvestri, M. Scardigli, G. Mannaioni, A. Masi
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Pharmacological Research
Subjects:
Autism
Valproic acid
Rapamycin
mTOR
Patch clamp
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822003462

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http://www.sciencedirect.com/science/article/pii/S1043661822003462

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