Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease.

Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease.

We aimed to investigate prevalence and prognostic role of SOX2, PIK3CA, FGFR1 and BRF2 gene gain in patients with surgically resected non-small cell lung cancer (NSCLC).SOX2, PIK3CA, FGFR1 and BRF2 gene copy number was assessed by fluorescence in situ hybridization (FISH) in arrayed tissue cores fro...

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Bibliographic Details
Main Authors: Luca Toschi, Giovanna Finocchiaro, Teresa T Nguyen, Margaret C Skokan, Laura Giordano, Letizia Gianoncelli, Matteo Perrino, Licia Siracusano, Luca Di Tommaso, Maurizio Infante, Marco Alloisio, Massimo Roncalli, Marta Scorsetti, Pasi A Jänne, Armando Santoro, Marileila Varella-Garcia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3988173?pdf=render

Internet

http://europepmc.org/articles/PMC3988173?pdf=render

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