TMT-Based Proteomics Analysis of Senescent Nucleus Pulposus from Patients with Intervertebral Disc Degeneration

TMT-Based Proteomics Analysis of Senescent Nucleus Pulposus from Patients with Intervertebral Disc Degeneration

Lower back pain, a leading cause of disability worldwide, is associated with intervertebral disc degeneration (IDD) in approximately 40% of cases. Although nucleus pulposus (NP) cell senescence is a major contributor to IDD, the underlying mechanisms remain unclear. We collected NP samples from IDD...

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Bibliographic Details
Main Authors: Guangzhi Zhang, Lei Li, Zhili Yang, Cangyu Zhang, Xuewen Kang
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
intervertebral disc degeneration
nucleus pulposus
proteomics
tandem mass tag
bioinformatics analysis
Online Access:https://www.mdpi.com/1422-0067/24/17/13236

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https://www.mdpi.com/1422-0067/24/17/13236

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