Drug-Induced Lysosomal Impairment Is Associated with the Release of Extracellular Vesicles Carrying Autophagy Markers

Drug-Induced Lysosomal Impairment Is Associated with the Release of Extracellular Vesicles Carrying Autophagy Markers

Amiodarone is a cationic amphiphilic drug used as an antiarrhythmic agent. It induces phospholipidosis, i.e., the accumulation of phospholipids within organelles of the endosomal–lysosomal system. Extracellular vesicles (EVs) are membrane-enclosed structures released by any type of cell and retrieve...

Full description

Bibliographic Details
Main Authors: Krizia Sagini, Sandra Buratta, Federica Delo, Roberto Maria Pellegrino, Stefano Giovagnoli, Lorena Urbanelli, Carla Emiliani
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
phospholipidosis
lysosomal storage disorders
amiodarone
chloroquine
bafilomycin A1
extracellular vesicles
Online Access:https://www.mdpi.com/1422-0067/22/23/12922

Internet

https://www.mdpi.com/1422-0067/22/23/12922

Similar Items