Construction and otological phenotypic characterization of a mouse model harboring orthologous human Waardenburg syndrome mutation SOX10 p.R106W

Construction and otological phenotypic characterization of a mouse model harboring orthologous human Waardenburg syndrome mutation SOX10 p.R106W

Objective To compare the otological phenotypic characteristics induced by Waardenburg syndrome mutation SOX10 p.R106W in mouse, miniature pig and human, and to construct a mouse model harboring orthologous human SOX10 p.R106W mutation. Methods By comparing the amino acid sequences of SOX10 proteins...

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Bibliographic Details
Main Authors: WANG Lulu, XIE Fei, ZHAO Qingyuan
Format: Article
Language:zho
Published: Editorial Office of Journal of Army Medical University 2023-12-01
Series:陆军军医大学学报
Subjects:
waardenburg syndrome
sox10
crispr/cas9
mouse model
Online Access:http://aammt.tmmu.edu.cn/html/202309001.htm

Internet

http://aammt.tmmu.edu.cn/html/202309001.htm

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