Cytotoxicity of Thioalkaloid-Enriched <i>Nuphar lutea</i> Extract and Purified 6,6′-Dihydroxythiobinupharidine in Acute Myeloid Leukemia Cells: The Role of Oxidative Stress and Intracellular Calcium

Cytotoxicity of Thioalkaloid-Enriched <i>Nuphar lutea</i> Extract and Purified 6,6′-Dihydroxythiobinupharidine in Acute Myeloid Leukemia Cells: The Role of Oxidative Stress and Intracellular Calcium

Acute myeloid leukemia (AML) is an aggressive hematological malignancy characterized by uncontrolled proliferation of immature myeloid progenitors. Here, we report the in vitro antileukemic effects of the sesquiterpene thioalkaloid-enriched fraction of the <i>Nuphar lutea</i> leaf extrac...

Full description

Bibliographic Details
Main Authors: Suchismita Muduli, Avi Golan-Goldhirsh, Jacob Gopas, Michael Danilenko
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceuticals
Subjects:
acute myeloid leukemia (AML)
water lily (<i>Nuphar lutea</i>) extract (NUP)
6,6′-dihydroxythiobinupharidine (DTBN)
apoptosis
reactive oxygen species (ROS)
oxidative stress
Online Access:https://www.mdpi.com/1424-8247/15/4/410

Internet

https://www.mdpi.com/1424-8247/15/4/410

Similar Items