Elagolix Sodium Salt and Its Synthetic Intermediates: A Spectroscopic, Crystallographic, and Conformational Study

Elagolix Sodium Salt and Its Synthetic Intermediates: A Spectroscopic, Crystallographic, and Conformational Study

Elagolix sodium salt is the first marketed orally active non-peptide gonadotropin-releasing hormone receptor antagonist (GnRHR-ant) for the management of hormone dependent diseases, such as endometriosis and uterine fibroids. Despite its presence on the market since 2018, a thorough NMR analysis of...

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Bibliographic Details
Main Authors: Samuele Ciceri, Diego Colombo, Enrico M. A. Fassi, Patrizia Ferraboschi, Giovanni Grazioso, Paride Grisenti, Marco Iannone, Carlo Castellano, Fiorella Meneghetti
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
GnRHR antagonist
endometriosis
uterine fibroids
atropisomerism
crystal structure
conformational analysis
Online Access:https://www.mdpi.com/1420-3049/28/9/3861

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https://www.mdpi.com/1420-3049/28/9/3861

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