Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors

Abstract The human 2-oxoglutarate dependent oxygenase aspartate/asparagine-β-hydroxylase (AspH) catalyses the hydroxylation of Asp/Asn-residues in epidermal growth factor-like domains (EGFDs). AspH is upregulated on the surface of malign cancer cells; increased AspH levels correlate with tumour inva...

全面介紹

書目詳細資料
Main Authors: Lennart Brewitz, Anthony Tumber, Inga Pfeffer, Michael A. McDonough, Christopher J. Schofield
格式: Article
語言:English
出版: Nature Portfolio 2020-05-01
叢編:Scientific Reports
在線閱讀:https://doi.org/10.1038/s41598-020-65123-9