A Review on DNA Repair Inhibition by PARP Inhibitors in Cancer Therapy
The DNA repair process protects the cells from DNA damaging agent by multiple pathways. Majority of the cancer therapy cause DNA damage which leads to apoptosis. The cell has natural ability to repair this damage which ultimately leads to development of resistance of drugs. The key enzymes involved...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2018-03-01
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| Series: | Folia Medica |
| Subjects: | |
| Online Access: | http://www.degruyter.com/view/j/folmed.2017.60.issue-1/folmed-2017-0067/folmed-2017-0067.xml?format=INT |
| _version_ | 1811244966784008192 |
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| author | Shah Ashish P. Patel Chhagan N. Sureja Dipen K. Sanghavi Kirtan P. |
| author_facet | Shah Ashish P. Patel Chhagan N. Sureja Dipen K. Sanghavi Kirtan P. |
| author_sort | Shah Ashish P. |
| collection | DOAJ |
| description | The DNA repair process protects the cells from DNA damaging agent by multiple pathways. Majority of the cancer therapy cause DNA damage which leads to apoptosis. The cell has natural ability to repair this damage which ultimately leads to development of resistance of drugs. The key enzymes involved in DNA repair process are poly(ADP-ribose) (PAR) and poly(ADP-ribose) polymerases (PARP). Tumor cells repair their defective gene via defective homologues recombination (HR) in the presence of enzyme PARP. PARP inhibitors inhibit the enzyme poly(ADP-ribose) polymerases (PARPs) which lead to apoptosis of cancer cells. Current clinical data shows the role of PARP inhibitors is not restricted to BRCA mutations but also effective in HR dysfunctions related tumors. Therefore, investigation in this area could be very helpful for future therapy of cancer. This review gives detail information on the role of PARP in DNA damage repair, the role of PARP inhibitors and chemistry of currently available PARP inhibitors. |
| first_indexed | 2024-04-12T14:33:22Z |
| format | Article |
| id | doaj.art-86f6f571fdba416d93142a0553e20bd9 |
| institution | Directory Open Access Journal |
| issn | 1314-2143 |
| language | English |
| last_indexed | 2024-04-12T14:33:22Z |
| publishDate | 2018-03-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Folia Medica |
| spelling | doaj.art-86f6f571fdba416d93142a0553e20bd92022-12-22T03:29:11ZengPensoft PublishersFolia Medica1314-21432018-03-01601394710.1515/folmed-2017-0067folmed-2017-0067A Review on DNA Repair Inhibition by PARP Inhibitors in Cancer TherapyShah Ashish P.0Patel Chhagan N.1Sureja Dipen K.2Sanghavi Kirtan P.3Department of Pharmacy, Sumandeep Vidyapeeth University, Vadodara, IndiaDepartment of Pharmaceutical Chemistry, Shree Sarvajanik Pharmacy College, Mehsana, IndiaDepartment of Pharmacy, Sumandeep Vidyapeeth University, Vadodara, IndiaDepartment of Pharmacy, Sumandeep Vidyapeeth University, Vadodara, IndiaThe DNA repair process protects the cells from DNA damaging agent by multiple pathways. Majority of the cancer therapy cause DNA damage which leads to apoptosis. The cell has natural ability to repair this damage which ultimately leads to development of resistance of drugs. The key enzymes involved in DNA repair process are poly(ADP-ribose) (PAR) and poly(ADP-ribose) polymerases (PARP). Tumor cells repair their defective gene via defective homologues recombination (HR) in the presence of enzyme PARP. PARP inhibitors inhibit the enzyme poly(ADP-ribose) polymerases (PARPs) which lead to apoptosis of cancer cells. Current clinical data shows the role of PARP inhibitors is not restricted to BRCA mutations but also effective in HR dysfunctions related tumors. Therefore, investigation in this area could be very helpful for future therapy of cancer. This review gives detail information on the role of PARP in DNA damage repair, the role of PARP inhibitors and chemistry of currently available PARP inhibitors.http://www.degruyter.com/view/j/folmed.2017.60.issue-1/folmed-2017-0067/folmed-2017-0067.xml?format=INTDNA damage repairPoly(ADP-ribose) polymerasesPARP inhibitorscancer |
| spellingShingle | Shah Ashish P. Patel Chhagan N. Sureja Dipen K. Sanghavi Kirtan P. A Review on DNA Repair Inhibition by PARP Inhibitors in Cancer Therapy Folia Medica DNA damage repair Poly(ADP-ribose) polymerases PARP inhibitors cancer |
| title | A Review on DNA Repair Inhibition by PARP Inhibitors in Cancer Therapy |
| title_full | A Review on DNA Repair Inhibition by PARP Inhibitors in Cancer Therapy |
| title_fullStr | A Review on DNA Repair Inhibition by PARP Inhibitors in Cancer Therapy |
| title_full_unstemmed | A Review on DNA Repair Inhibition by PARP Inhibitors in Cancer Therapy |
| title_short | A Review on DNA Repair Inhibition by PARP Inhibitors in Cancer Therapy |
| title_sort | review on dna repair inhibition by parp inhibitors in cancer therapy |
| topic | DNA damage repair Poly(ADP-ribose) polymerases PARP inhibitors cancer |
| url | http://www.degruyter.com/view/j/folmed.2017.60.issue-1/folmed-2017-0067/folmed-2017-0067.xml?format=INT |
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