YwqL (EndoV), ExoA and PolA act in a novel alternative excision pathway to repair deaminated DNA bases in Bacillus subtilis.

YwqL (EndoV), ExoA and PolA act in a novel alternative excision pathway to repair deaminated DNA bases in Bacillus subtilis.

DNA deamination generates base transitions and apurinic/apyrimidinic (AP)-sites which are potentially genotoxic and cytotoxic. In Bacillus subtilis uracil can be removed from DNA by the uracil DNA-glycosylase through the base excision repair pathway. Genetic evidence suggests that B. subtilis YwqL,...

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Main Authors: Adriana G Patlán, Víctor M Ayala-García, Luz I Valenzuela-García, Jimena Meneses-Plascencia, Pedro L Vargas-Arias, Marcelo Barraza-Salas, Peter Setlow, Luis G Brieba, Mario Pedraza-Reyes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0211653

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https://doi.org/10.1371/journal.pone.0211653

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