Involvement of stimulation of α7 nicotinic acetylcholine receptors in the suppressive effect of tropisetron on dextran sulfate sodium-induced colitis in mice

Involvement of stimulation of α7 nicotinic acetylcholine receptors in the suppressive effect of tropisetron on dextran sulfate sodium-induced colitis in mice

Ulcerative colitis (UC) involves chronic inflammation of the large intestine. Several agents are used to treat UC, but adverse side effects are remaining problems. We examined the effect of tropisetron as a new type of drug for UC using a dextran sulfate sodium (DSS)-induced model of colitis in mice...

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Bibliographic Details
Main Authors: Yuichi Tasaka, Daiki Yasunaga, Takeshi Kiyoi, Mamoru Tanaka, Akihiro Tanaka, Katsuya Suemaru, Hiroaki Araki
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Journal of Pharmacological Sciences
Subjects:
Ulcerative colitis
Cholinergic
Anti-inflammatory
α7 nACh receptor
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131500033X

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http://www.sciencedirect.com/science/article/pii/S134786131500033X

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