Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes.

Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes.

Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of glucose homeostasis and body mass, and has been implicated in endoplasmic reticulum (ER) stress. Herein, we assess the role of PTP1B in ER stress in brown adipocytes, which are key regulators of thermogenesis and metabolic respo...

Full description

Bibliographic Details
Main Authors: Ahmed Bettaieb, Kosuke Matsuo, Izumi Matsuo, Shuo Wang, Ramzi Melhem, Antonis E Koromilas, Fawaz G Haj
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3317973?pdf=render

Internet

http://europepmc.org/articles/PMC3317973?pdf=render

Similar Items