Infliximab inhibits TNF-α-dependent activation of the NLRP3/IL-1β pathway in acne inversa

Infliximab inhibits TNF-α-dependent activation of the NLRP3/IL-1β pathway in acne inversa

Background: Acne inversa (AI) is a refractory inflammatory skin disease, and TNF-α plays an important role in the pathogenesis of AI. By blocking TNF-α, infliximab (IFX) has been proven to be a promising method. Objectives: To explore the underlying mechanisms of IFX treatment in AI patients. Method...

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Bibliographic Details
Main Authors: Yanyan He, Wenzhu Wang, Juan Jiang, Yuanxing Shen, Baoxi Wang, Jiangning Chen, Min Li, Haoxiang Xu
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Heliyon
Subjects:
Acne inversa
Infliximab
TNF-α
IL-1β
NLRP3
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024091771

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http://www.sciencedirect.com/science/article/pii/S2405844024091771

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