Analysis of Primary Cilium Expression and Hedgehog Pathway Activation in Mesothelioma Throws Back Its Complex Biology

Analysis of Primary Cilium Expression and Hedgehog Pathway Activation in Mesothelioma Throws Back Its Complex Biology

The primary cilium (PC) is a sensory organelle present on the cell surface, modulating the activity of many pathways. Dysfunctions in the PC lead to different pathologic conditions including cancer. Hedgehog signaling (Hh) is regulated by PC and the loss of its control has been observed in many canc...

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Bibliographic Details
Main Authors: Marcella Barbarino, Maria Bottaro, Laura Spagnoletti, Maria Margherita de Santi, Raffaella Guazzo, Chiara Defraia, Cosimo Custoza, Gabriella Serio, Francesco Iannelli, Matilde Pesetti, Raffaele Aiello, Diletta Rosati, Edoardo Zanfrini, Luca Luzzi, Cristiana Bellan, Antonio Giordano
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
primary cilium
mesothelioma
pleural
hedgehog signaling
GLI1
Online Access:https://www.mdpi.com/2072-6694/14/21/5216

Internet

https://www.mdpi.com/2072-6694/14/21/5216

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