Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others.

Over the last few years, thalidomide has become one of the most important anti-tumour drugs for the treatment of relapsed-refractory multiple myeloma. However, besides its undesirable teratogenic side effect, its configurational instability critically limits any further therapeutic improvements of t...

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Bibliographic Details
Main Authors: Etsuko Tokunaga, Hidehiko Akiyama, Vadim A Soloshonok, Yuki Inoue, Hideaki Hara, Norio Shibata
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5538663?pdf=render