Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

Aberrant chromatin structure is often found in cancer. Here, the authors optimise super-resolution microscopy for pathological tissue and discovered a significant decompaction of chromatin folding in early carcinogenesis prior to tumour formation.

Bibliographic Details
Main Authors: Jianquan Xu, Hongqiang Ma, Hongbin Ma, Wei Jiang, Christopher A. Mela, Meihan Duan, Shimei Zhao, Chenxi Gao, Eun-Ryeong Hahm, Santana M. Lardo, Kris Troy, Ming Sun, Reet Pai, Donna B. Stolz, Lin Zhang, Shivendra Singh, Randall E. Brand, Douglas J. Hartman, Jing Hu, Sarah J. Hainer, Yang Liu
Format: Article
Language:English
Published: Nature Portfolio 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15718-7

Internet

https://doi.org/10.1038/s41467-020-15718-7

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