Identification of DAPK1 Promoter Hypermethylation as a Biomarker for Intra-Epithelial Lesion and Cervical Cancer: A Meta-Analysis of Published Studies, TCGA, and GEO Datasets

Identification of DAPK1 Promoter Hypermethylation as a Biomarker for Intra-Epithelial Lesion and Cervical Cancer: A Meta-Analysis of Published Studies, TCGA, and GEO Datasets

Background: Promoter hypermethylation in death-associated protein kinase 1 (DAPK1) gene has been long linked to cervical neoplasia, but the established results remained controversial. Here, we performed a meta-analysis to assess the associations of DAPK1 promoter hypermethylation with low-grade intr...

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Bibliographic Details
Main Authors: Xue-bin Wang, Ning-hua Cui, Xia-nan Liu, Jun-fen Ma, Qing-hua Zhu, Shu-ren Guo, Jun-wei Zhao, Liang Ming
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Genetics
Subjects:
DAPK1 promoter hypermethylation
cervical cancer
intra-epithelial lesion
TCGA database
GEO database
meta-analysis
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00258/full

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https://www.frontiersin.org/article/10.3389/fgene.2018.00258/full

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