BTLA-derived peptides as inhibitors of BTLA/HVEM complex formation – design, synthesis and biological evaluation

BTLA-derived peptides as inhibitors of BTLA/HVEM complex formation – design, synthesis and biological evaluation

Immune checkpoints can be divided into co-stimulatory and co-inhibitory molecules that regulate the activation and effector functions of T cells. The co-inhibitory pathways mediated by ICPs are used by cancer cells to escape from immune surveillance, and therefore the blockade of these receptor/liga...

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Bibliographic Details
Main Authors: Katarzyna Kuncewicz, Magdalena Bojko, Claire Battin, Agnieszka Karczyńska, Adam Sieradzan, Emilia Sikorska, Katarzyna Węgrzyn, Karolina Wojciechowicz, Anna Wardowska, Peter Steinberger, Sylwia Rodziewicz-Motowidło, Marta Spodzieja
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
BTLA
HVEM
Immunotherapy
Immune checkpoint
Peptide inhibitor
Structure-based design
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223009526

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http://www.sciencedirect.com/science/article/pii/S0753332223009526

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