Interactions of Paraoxonase-1 with Pharmacologically Relevant Carbamates

Interactions of Paraoxonase-1 with Pharmacologically Relevant Carbamates

Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant PON1 (rePON1). Carbamates were selected having a variety of applications: bambuterol and physostig...

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Bibliographic Details
Main Authors: Anita Bosak, Aljoša Bavec, Tilen Konte, Goran Šinko, Zrinka Kovarik, Marko Goličnik
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
paraoxonase-1
arylesterase activity
phenyl acetate
<i>s</i>-phenyl thioacetate
<i>p</i>-nitrophenyl acetate
carbamates
reversible inhibition
Online Access:https://www.mdpi.com/1420-3049/25/1/211

Internet

https://www.mdpi.com/1420-3049/25/1/211

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