Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners

Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners

Effects of a pan-ROCK-inhibitor, ripasudil (Rip), and a ROCK2 inhibitor, KD025 on dexamethasone (DEX)-treated human trabecular meshwork (HTM) cells as a model of steroid-induced glaucoma were investigated. In the presence of Rip or KD025, DEX-treated HTM cells were subjected to permeability analysis...

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Bibliographic Details
Main Authors: Megumi Watanabe, Yosuke Ida, Masato Furuhashi, Yuri Tsugeno, Fumihito Hikage, Hiroshi Ohguro
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
3D spheroid cultures
human trabecular meshwork (HTM)
Rho-associated coiled-coil containing protein kinase (ROCK)
ripasudil
KD025
dexamethasone
Online Access:https://www.mdpi.com/1420-3049/26/21/6382

Internet

https://www.mdpi.com/1420-3049/26/21/6382

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