Monomethyl lithospermate alleviates ischemic stroke injury in middle cerebral artery occlusion mice in vivo and protects oxygen glucose deprivation/reoxygenation induced SHSY-5Y cells in vitro via activation of PI3K/Akt signaling

Monomethyl lithospermate alleviates ischemic stroke injury in middle cerebral artery occlusion mice in vivo and protects oxygen glucose deprivation/reoxygenation induced SHSY-5Y cells in vitro via activation of PI3K/Akt signaling

Stroke is a fatal neurological disease, which seriously threatens human health and life. Ischemic stroke (IS) is the most common type of stroke in clinic. Its pathogenesis is very complex, mainly caused by nerve damage caused by brain blood supply disorder. Previous studies have confirmed that natur...

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Bibliographic Details
Main Authors: Fang Yang, Ze-Ran Chen, Xu-Hong Yang, Yue Xu, Ning-Jing Ran, Mei-Jun Liu, Shuo-Guo Jin, Hua-Nan Jia, Yang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
stroke
ischemic stroke
ischemia-reperfusion
neural damage
PI3K/Akt pathway
OGR/R
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1024439/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1024439/full

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