Polycomb repressor complex: Its function in human cancer and therapeutic target strategy
The Polycomb Repressor Complex (PRC) plays a pivotal role in gene regulation during development and disease, with dysregulation contributing significantly to various human cancers. The intricate interplay between PRC and cellular signaling pathways sheds light on cancer complexity. PRC presents prom...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223016955 |
| _version_ | 1797404584582316032 |
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| author | Jingrong Liu Hongjie Fan Xinmiao Liang Yang Chen |
| author_facet | Jingrong Liu Hongjie Fan Xinmiao Liang Yang Chen |
| author_sort | Jingrong Liu |
| collection | DOAJ |
| description | The Polycomb Repressor Complex (PRC) plays a pivotal role in gene regulation during development and disease, with dysregulation contributing significantly to various human cancers. The intricate interplay between PRC and cellular signaling pathways sheds light on cancer complexity. PRC presents promising therapeutic opportunities, with inhibitors undergoing rigorous evaluation in preclinical and clinical studies. In this review, we emphasize the critical role of PRC complex in gene regulation, particularly PcG proteins mediated chromatin compaction through phase separation. We also highlight the pathological implications of PRC complex dysregulation in various tumors, elucidating underlying mechanisms driving cancer progression. The burgeoning field of therapeutic strategies targeting PRC complexes, notably EZH2 inhibitors, has advanced significantly. However, we explore the need for combination therapies to enhance PRC targeted treatments efficacy, providing a glimpse into the future of cancer therapeutics. |
| first_indexed | 2024-03-09T02:57:08Z |
| format | Article |
| id | doaj.art-8720bf71936f48b796071ade2cd30e0b |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-09T02:57:08Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-8720bf71936f48b796071ade2cd30e0b2023-12-05T04:14:43ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-12-01169115897Polycomb repressor complex: Its function in human cancer and therapeutic target strategyJingrong Liu0Hongjie Fan1Xinmiao Liang2Yang Chen3Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, ChinaGanjiang Chinese Medicine Innovation Center, Nanchang 330000, ChinaGanjiang Chinese Medicine Innovation Center, Nanchang 330000, China; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; Corresponding authors at: Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, China.Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, China; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; Corresponding authors at: Ganjiang Chinese Medicine Innovation Center, Nanchang 330000, China.The Polycomb Repressor Complex (PRC) plays a pivotal role in gene regulation during development and disease, with dysregulation contributing significantly to various human cancers. The intricate interplay between PRC and cellular signaling pathways sheds light on cancer complexity. PRC presents promising therapeutic opportunities, with inhibitors undergoing rigorous evaluation in preclinical and clinical studies. In this review, we emphasize the critical role of PRC complex in gene regulation, particularly PcG proteins mediated chromatin compaction through phase separation. We also highlight the pathological implications of PRC complex dysregulation in various tumors, elucidating underlying mechanisms driving cancer progression. The burgeoning field of therapeutic strategies targeting PRC complexes, notably EZH2 inhibitors, has advanced significantly. However, we explore the need for combination therapies to enhance PRC targeted treatments efficacy, providing a glimpse into the future of cancer therapeutics.http://www.sciencedirect.com/science/article/pii/S0753332223016955Polycomb repressor complexEpigenetic modificationTumorigenesisCancer progressionTherapeutic target |
| spellingShingle | Jingrong Liu Hongjie Fan Xinmiao Liang Yang Chen Polycomb repressor complex: Its function in human cancer and therapeutic target strategy Biomedicine & Pharmacotherapy Polycomb repressor complex Epigenetic modification Tumorigenesis Cancer progression Therapeutic target |
| title | Polycomb repressor complex: Its function in human cancer and therapeutic target strategy |
| title_full | Polycomb repressor complex: Its function in human cancer and therapeutic target strategy |
| title_fullStr | Polycomb repressor complex: Its function in human cancer and therapeutic target strategy |
| title_full_unstemmed | Polycomb repressor complex: Its function in human cancer and therapeutic target strategy |
| title_short | Polycomb repressor complex: Its function in human cancer and therapeutic target strategy |
| title_sort | polycomb repressor complex its function in human cancer and therapeutic target strategy |
| topic | Polycomb repressor complex Epigenetic modification Tumorigenesis Cancer progression Therapeutic target |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223016955 |
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