Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the identification of a patient with a novel mutation in...

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Bibliographic Details
Main Authors: Alex F Thompson, Patrick R Blackburn, Noah S Arons, Sarah N Stevens, Dusica Babovic-Vuksanovic, Jane B Lian, Eric W Klee, Jason Stumpff
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
chromokinesin
mitosis
mitotic spindle
KIF22
Online Access:https://elifesciences.org/articles/78653

Internet

https://elifesciences.org/articles/78653

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