Systematic Assessment of Human CCR7 Signalling Using NanoBRET Biosensors Points towards the Importance of the Cellular Context

Systematic Assessment of Human CCR7 Signalling Using NanoBRET Biosensors Points towards the Importance of the Cellular Context

The human CC chemokine receptor 7 (CCR7) is activated by two natural ligands, CC chemokine ligand 19 (CCL19) and 21 (CCL21). The CCL19-CCL21-CCR7 axis has been extensively studied in vitro, but there is still debate over whether CCL21 is an overall weaker agonist or if the axis displays biased signa...

Full description

Bibliographic Details
Main Authors: Nathan Vanalken, Katrijn Boon, Martyna Szpakowska, Andy Chevigné, Dominique Schols, Tom Van Loy
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biosensors
Subjects:
G protein-coupled receptor
chemokine receptor
CCR7
ligand bias
biased signalling
G protein
Online Access:https://www.mdpi.com/2079-6374/14/3/142

Internet

https://www.mdpi.com/2079-6374/14/3/142

Similar Items