Efficient isolation of rare B cells using next-generation antigen barcoding

Efficient isolation of rare B cells using next-generation antigen barcoding

The ability to efficiently isolate antigen-specific B cells in high throughput will greatly accelerate the discovery of therapeutic monoclonal antibodies (mAbs) and catalyze rational vaccine development. Traditional mAb discovery is a costly and labor-intensive process, although recent advances in s...

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Bibliographic Details
Main Authors: Jonathan Hurtado, Claudia Flynn, Jeong Hyun Lee, Eugenia C. Salcedo, Christopher A. Cottrell, Patrick D. Skog, Dennis R. Burton, David Nemazee, William R. Schief, Elise Landais, Devin Sok, Bryan Briney
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
antibody
BCR
immunology
single cell
multi-omics
humoral immunology
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.962945/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.962945/full

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