DropletQC: improved identification of empty droplets and damaged cells in single-cell RNA-seq data
Abstract Background Advances in droplet-based single-cell RNA-sequencing (scRNA-seq) have dramatically increased throughput, allowing tens of thousands of cells to be routinely sequenced in a single experiment. In addition to cells, droplets capture cell-free “ambient” RNA predominantly caused by ly...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-12-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-021-02547-0 |