Potential diagnostic value of CSF metabolism-related proteins across the Alzheimer’s disease continuum

Potential diagnostic value of CSF metabolism-related proteins across the Alzheimer’s disease continuum

Abstract Background Alzheimer’s disease (AD) cerebrospinal fluid (CSF) core biomarkers (Aβ42/40 ratio, p-tau, and t-tau) provide high diagnostic accuracy, even at the earliest stage of disease. However, these markers do not fully reflect the complex AD pathophysiology. Recent large scale CSF proteom...

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Bibliographic Details
Main Authors: Silvia Paciotti, Anna Lidia Wojdała, Giovanni Bellomo, Andrea Toja, Elena Chipi, Sander R. Piersma, Thang V. Pham, Lorenzo Gaetani, Connie R. Jimenez, Lucilla Parnetti, Davide Chiasserini
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Cerebrospinal fluid
Biomarkers
Preclinical AD
Pyruvate kinase
Aldolase
Online Access:https://doi.org/10.1186/s13195-023-01269-8

Internet

https://doi.org/10.1186/s13195-023-01269-8

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