Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data

Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data

Abstract Background Digoxin is an important treatment option for reducing the ventricular rate in patients with atrial fibrillation (AF) and heart failure (HF). Digoxin has a narrow therapeutic window and large interindividual variability. A low target blood concentration, especially ≤0.9 ng/mL, is...

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Bibliographic Details
Main Authors: Toshinori Hirai, Hidefumi Kasai, Miyoko Naganuma, Nobuhisa Hagiwara, Tsuyoshi Shiga
Format: Article
Language:English
Published: BMC 2022-02-01
Series:BMC Pharmacology and Toxicology
Subjects:
Atrial fibrillation
Amiodarone
Creatinine clearance
Digoxin
Heart failure
Population pharmacokinetics
Online Access:https://doi.org/10.1186/s40360-022-00552-y

Internet

https://doi.org/10.1186/s40360-022-00552-y

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