Role of Glutathione Peroxidase 4 in Glutamate-Induced Oxytosis in the Retina.

The purpose of the present study was to investigate the role of glutathione peroxidase 4 (GPx4) in glutamate-induced oxytosis in the retina.For in vitro studies, an immortalized rat retinal precursor cell line R28 was used. Cells were transfected with siRNA specifically silencing GPx4 or with scramb...

Full description

Bibliographic Details
Main Authors: Osamu Sakai, Takatoshi Uchida, Murilo F Roggia, Hirotaka Imai, Takashi Ueta, Shiro Amano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4470664?pdf=render