ER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation

ER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation

Summary: The transcription factor NRF1 resides in the endoplasmic reticulum (ER) and is constantly transported to the cytosol for proteasomal degradation. However, when the proteasome is defective, NRF1 escapes degradation and undergoes proteolytic cleavage by the protease DDI2, generating a transcr...

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Bibliographic Details
Main Authors: Claire Chavarria, Léa Zaffalon, Sérgio T. Ribeiro, Mélanie Op, Manfredo Quadroni, Maria Sofia Iatrou, Chloé Chapuis, Fabio Martinon
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Biochemistry
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223018540

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223018540

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