A Fast Multi-Locus Ridge Regression Algorithm for High-Dimensional Genome-Wide Association Studies

A Fast Multi-Locus Ridge Regression Algorithm for High-Dimensional Genome-Wide Association Studies

The mixed linear model (MLM) has been widely used in genome-wide association study (GWAS) to dissect quantitative traits in human, animal, and plant genetics. Most methodologies consider all single nucleotide polymorphism (SNP) effects as random effects under the MLM framework, which fail to detect...

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Bibliographic Details
Main Authors: Jin Zhang, Min Chen, Yangjun Wen, Yin Zhang, Yunan Lu, Shengmeng Wang, Juncong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
genome-wide association study
mixed linear model
multi-locus algorithm
statistical power
polygenic background
minor effect
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.649196/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.649196/full

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