PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair

PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair

Tissues and organs undergo structural deterioration and functional decline during aging. DNA damage is considered a major cause of stem cell senescence. Although stem cells develop sophisticated DNA repair systems, when the intrinsic and extrinsic insults exceed the DNA repair capacity, cellular sen...

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Bibliographic Details
Main Authors: Yuan Wang, Yutong Sui, Aobo Lian, Xing Han, Feilin Liu, Kuiyang Zuo, Mingsheng Liu, Wei Sun, Ziyu Wang, Zinan Liu, Fei Zou, Rifeng Lu, Minghua Jin, Haiying Du, Kan Xu, Xiaomei Liu, Jinyu Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PBX1
hair follicle (HF)
mesenchymal stem cells
senescence
apoptosis
DNA damage and repair
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.739868/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.739868/full

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