A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans.

A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans.

Genetic pathways that regulate nascent neurite formation play a critical role in neuronal morphogenesis. The core planar cell polarity components VANG-1/Van Gogh and PRKL-1/Prickle are involved in blocking inappropriate neurite formation in a subset of motor neurons in C. elegans. A genetic screen f...

Full description

Bibliographic Details
Main Authors:	David Carr, Leticia Sanchez-Alvarez, Janice H Imai, Cristina Slatculescu, Nathaniel Noblett, Lei Mao, Lorena Beese, Antonio Colavita
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4907426?pdf=render

Similar Items

VANG-1 and PRKL-1 cooperate to negatively regulate neurite formation in Caenorhabditis elegans.
by: Leticia Sanchez-Alvarez, et al.
Published: (2011-09-01)

Thematic review series: Lipid Posttranslational Modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I
by: Kimberly T. Lane, et al.
Published: (2006-04-01)

Farnesyltransferase inhibitors.
by: Hahn, S, et al.
Published: (2001)

Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase.
by: Hast, M, et al.
Published: (2009)

Farnesyltransferase inhibitors as radiation sensitizers.
by: Brunner, T, et al.
Published: (2003)

Farnesyltransferase inhibitors as radiation sensitizers.
by: Mckenna, W, et al.
Published: (2002)

Farnesyltransferase inhibitors as radiation sensitizers
by: Mckenna, W
Published: (2005)

The regulatory landscape of neurite development in Caenorhabditis elegans
by: Rasoul Godini, et al.
Published: (2022-08-01)

Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor
by: Rothstein Jay L, et al.
Published: (2008-02-01)

Farnesyltransferase-inhibitors exert in vitro immunosuppressive capacity by inhibiting human B-cells
by: Shilei Xu, et al.
Published: (2023-11-01)

Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells
by: Yufang Ma, et al.
Published: (2017-12-01)

Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
by: Fletcher, S, et al.
Published: (2010)

Bacteria Are New Targets for Inhibitors of Human Farnesyltransferase
by: Lea Weber, et al.
Published: (2021-11-01)

Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations.
by: Brunner, T, et al.
Published: (2003)

Exploring Protoheme IX Farnesyltransferase as an Antimalarial Drug Target
by: Edelen, Samantha Leigh
Published: (2022)

Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase
by: Anna Hagemann, et al.
Published: (2022-12-01)

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy
by: Xiaohan Dai, et al.
Published: (2020-01-01)

Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
by: Nguyen Thi Ha, et al.
Published: (2020-10-01)

Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni
by: Alexandra Probst, et al.
Published: (2019-05-01)

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria
by: Shao H. Yang, et al.
Published: (2010-02-01)

Molecular mechanisms of neurite regeneration and repair: insights from C. elegans and Drosophila
by: Xiaofan Liu, et al.
Published: (2023-04-01)

Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans
by: Menghao Lu, et al.
Published: (2019-12-01)

Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
by: Van Voorhis, W, et al.
Published: (2007)

New indazole-indolizine-triazine hybrid molecules with farnesyltransferase inhibitory activity
by: Liliana Ciurlă-Lucescu, et al.
Published: (2024-01-01)

Phenothiazine- and Carbazole-Cyanochalcones as Dual Inhibitors of Tubulin Polymerization and Human Farnesyltransferase
by: Andreea Zubaș, et al.
Published: (2023-06-01)

MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase
by: Garrett L. Schey, et al.
Published: (2021-11-01)

A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans.
by: Song Song, et al.
Published: (2010-08-01)

Suppression of NASH-Related HCC by Farnesyltransferase Inhibitor through Inhibition of Inflammation and Hypoxia-Inducible Factor-1α Expression
by: Kohei Yamada, et al.
Published: (2023-07-01)

The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites
by: Jana Dorfman Marcette, et al.
Published: (2014-02-01)

Effects of MAP4K inhibition on neurite outgrowth
by: Di Ja Lasham, et al.
Published: (2023-11-01)

Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104)
by: Gajewski Thomas F, et al.
Published: (2012-12-01)

Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
by: Leah K. Cuddy, et al.
Published: (2022-08-01)

Virtual Lead Identification of Farnesyltransferase Inhibitors Based on Ligand and Structure-Based Pharmacophore Techniques
by: Nizar M. Mhaidat, et al.
Published: (2013-05-01)

123I-EGF internalisation in tumour cells in vitro is inhibited by farnesyltransferase inhibitor therapy: possible target for early therapy response prediction
by: Cornelissen, B, et al.
Published: (2004)

rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans.
by: Alexander T Lin-Moore, et al.
Published: (2021-11-01)

Ectopic fat deposition contributes to age-associated pathology in Caenorhabditis elegans
by: Konstantinos Palikaras, et al.
Published: (2017-01-01)

The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.
by: Cohen-Jonathan, E, et al.
Published: (2001)

Chimeric ZHHH neuroglobin acts as a cell membrane‐penetrating inducer of neurite outgrowth
by: Nozomu Takahashi, et al.
Published: (2017-09-01)

Genetic analysis of a novel tubulin mutation that redirects synaptic vesicle targeting and causes neurite degeneration in C. elegans.
by: Jiun-Min Hsu, et al.
Published: (2014-11-01)

Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS.
by: Cohen-Jonathan, E, et al.
Published: (2000)