PAM variants in patients with thyrotrophinomas, cyclical Cushing’s disease and prolactinomas

PAM variants in patients with thyrotrophinomas, cyclical Cushing’s disease and prolactinomas

IntroductionGermline loss-of-function variants in PAM, encoding peptidylglycine α-amidating monooxygenase (PAM), were recently discovered to be enriched in conditions of pathological pituitary hypersecretion, specifically: somatotrophinoma, corticotrophinoma, and prolactinoma. PAM is the sole enzyme...

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Bibliographic Details
Main Authors: Sunita M. C. De Sousa, Angeline Shen, Christopher J. Yates, Roderick Clifton-Bligh, Stephen Santoreneos, James King, John Toubia, Giampaolo Trivellin, Andrea G. Lania, Constantine A. Stratakis, David J. Torpy, Hamish S. Scott
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Endocrinology
Subjects:
peptidylglycine α-amidating monooxygenase
whole exome sequencing
Cushing’s disease
prolactinoma
thyrotrophinoma
pituitary adenomas
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1305606/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1305606/full

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