Tailoring Ovarian Cancer Treatment: Implications of <i>BRCA1/2</i> Mutations

Tailoring Ovarian Cancer Treatment: Implications of <i>BRCA1/2</i> Mutations

High grade serous ovarian cancer (HGSOC) is the most common epithelial ovarian cancer, harbouring more than 20% germline or somatic mutations in the tumour suppressor genes <i>BRCA1</i> and <i>BRCA2</i>. These genes are involved in both DNA damage repair process via homologou...

Full description

Bibliographic Details
Main Authors: Ainhoa Madariaga, Stephanie Lheureux, Amit M. Oza
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
ovarian cancer
<i>BRCA</i> mutation
homologous recombination
treatment
platinum
PARP inhibitor
resistance
Online Access:https://www.mdpi.com/2072-6694/11/3/416

Internet

https://www.mdpi.com/2072-6694/11/3/416

Similar Items