Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling

Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling

Abstract Pancreatic ductal adenocarcinoma (PDAC) patients display distinct phenotypes of cachexia development, with either adipose tissue loss preceding skeletal muscle wasting or loss of only adipose tissue. Activin A levels were measured in serum and analyzed in tumor specimens of both a cohort of...

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Bibliographic Details
Main Authors: Pauline C. Xu, Mikyoung You, Seok-Yeong Yu, Yi Luan, Maya Eldani, Thomas C. Caffrey, Paul M. Grandgenett, Kelly A. O’Connell, Surendra K. Shukla, Chandramohan Kattamuri, Michael A. Hollingsworth, Pankaj K. Singh, Thomas B. Thompson, Soonkyu Chung, So-Youn Kim
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-05660-7

Internet

https://doi.org/10.1038/s41598-022-05660-7

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