Xanthine oxidase inhibitory potentials of flavonoid aglycones of Tribulus terrestris: in vivo, in silico and in vitro studies

Xanthine oxidase inhibitory potentials of flavonoid aglycones of Tribulus terrestris: in vivo, in silico and in vitro studies

Abstract Background Despite the ongoing safety-driven spate of flavonoid xanthine oxidase (XOD) inhibition investigations, there is a lack of flavonoid-based uricostatic antihyperuricemic agents in clinical medicine. The poor pharmacokinetic profiles of glycosides (the natural form of existence of m...

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Bibliographic Details
Main Authors: Olusegun Samson Ajala, Ayotomiwa Olubusayo Ayeleso, Mbang Owolabi, Moshood Olusola Akinleye, Grace Ukpo
Format: Article
Language:English
Published: SpringerOpen 2022-12-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
In silico drug discovery
Flavonoid aglycones
Hyperuricemia
Xanthine oxidase inhibition
Online Access:https://doi.org/10.1186/s43094-022-00448-y

Internet

https://doi.org/10.1186/s43094-022-00448-y

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