CODEX2: full-spectrum copy number variation detection by high-throughput DNA sequencing

CODEX2: full-spectrum copy number variation detection by high-throughput DNA sequencing

Abstract High-throughput DNA sequencing enables detection of copy number variations (CNVs) on the genome-wide scale with finer resolution compared to array-based methods but suffers from biases and artifacts that lead to false discoveries and low sensitivity. We describe CODEX2, as a statistical fra...

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Bibliographic Details
Main Authors: Yuchao Jiang, Rujin Wang, Eugene Urrutia, Ioannis N. Anastopoulos, Katherine L. Nathanson, Nancy R. Zhang
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Genome Biology
Subjects:
Copy number variation
Normalization
Next-generation sequencing
Latent factor
Negative control
Online Access:http://link.springer.com/article/10.1186/s13059-018-1578-y

Internet

http://link.springer.com/article/10.1186/s13059-018-1578-y

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