Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin

Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin

Abstract Background V(D) J recombination is essential for adaptive immunity in jawed vertebrates and is initiated by the RAG1-RAG2 endonuclease. The RAG1 and RAG2 genes are thought to have evolved from a RAGL (RAG-like) transposon containing convergently-oriented RAG1-like (RAG1L) and RAG2-like (RAG...

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Bibliographic Details
Main Authors: Eliza C. Martin, Célia Vicari, Louis Tsakou-Ngouafo, Pierre Pontarotti, Andrei J. Petrescu, David G. Schatz
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Mobile DNA
Subjects:
Recombination activating genes
RAG
Evolution
Transposon
Adaptive immunity
Transposon molecular domestication
Online Access:http://link.springer.com/article/10.1186/s13100-020-00214-y

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http://link.springer.com/article/10.1186/s13100-020-00214-y

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