GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults

GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults

Abstract Mitochondrial dysfunction and reactive oxygen species (ROS) accumulation within the substantia nigra pars compacta (SNpc) are central drivers of dopaminergic (DA) neuron death in Parkinson’s disease (PD). Guanylyl cyclases and their second messenger cyclic (c)GMP support mitochondrial funct...

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Bibliographic Details
Main Authors: Lara Cheslow, Matthew Byrne, Jessica S. Kopenhaver, Lorraine Iacovitti, Richard J. Smeyne, Adam E. Snook, Scott A. Waldman
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-024-00697-z

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https://doi.org/10.1038/s41531-024-00697-z

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