Inhibition of Vascular c‐Jun N‐Terminal Kinase 2 Improves Obesity‐Induced Endothelial Dysfunction After Roux‐en‐Y Gastric Bypass

Inhibition of Vascular c‐Jun N‐Terminal Kinase 2 Improves Obesity‐Induced Endothelial Dysfunction After Roux‐en‐Y Gastric Bypass

BackgroundRoux‐en‐Y gastric bypass (RYGB) reduces obesity‐associated comorbidities and cardiovascular mortality. RYGB improves endothelial dysfunction, reducing c‐Jun N‐terminal kinase (JNK) vascular phosphorylation. JNK activation links obesity with insulin resistance and endothelial dysfunction. H...

Full description

Bibliographic Details
Main Authors: Petia Doytcheva, Thomas Bächler, Erika Tarasco, Vincenzo Marzolla, Michael Engeli, Giovanni Pellegrini, Simona Stivala, Lucia Rohrer, Francesco Tona, Giovanni G. Camici, Paul M. Vanhoutte, Christian M. Matter, Thomas A. Lutz, Thomas F. Lüscher, Elena Osto
Format: Article
Language:English
Published: Wiley 2017-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
bariatric surgery
c‐Jun N‐terminal kinase
endothelial function
glucagon‐like peptide‐1
NO
obesity
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.006441

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.117.006441

Similar Items