IRGM/Irgm1 increases autophagy to inhibit activation of NLRP3 inflammasome in inflammatory injury induced acute liver failure

IRGM/Irgm1 increases autophagy to inhibit activation of NLRP3 inflammasome in inflammatory injury induced acute liver failure

Abstract Immune-related GTPase M (IRGM) induces autophagy and suppresses inflammation, but its putative role and signaling mechanism remain undefined in the pathogenesis of liver failure. This study aimed to address how IRGM attenuates inflammatory injury by regulating autophagy in liver failure. In...

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Bibliographic Details
Main Authors: Xing Zhang, Yangyang Hu, Wei Wang, Ru Ji, Ziyue Li, Weiyan Yu, Zhinian Wu, Ying Xiao, Tingyu Guo, Zeqiang Qi, Yadong Wang, Caiyan Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2024-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02052-w

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https://doi.org/10.1038/s41420-024-02052-w

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