WSB1, as an E3 ligase, restrains myocardial ischemia–reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination

WSB1, as an E3 ligase, restrains myocardial ischemia–reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination

Abstract Background Reperfusion is the most effective strategy for myocardial infarct, but induces additional injury. WD repeat and SOCS box containing protein 1 (WSB1) plays a protective role in ischemic cells. This study aims to investigate the effects of WSB1 on myocardial ischemia–reperfusion (I...

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Bibliographic Details
Main Authors: Lini Fang, Yang Tao, Guoying Che, Yongzi Yun, Min Ren, Yujie Liu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Molecular Medicine
Subjects:
Myocardial ischemia–reperfusion
WSB1
β-catenin
GSK3β
Ubiquitination
Online Access:https://doi.org/10.1186/s10020-024-00800-3

Internet

https://doi.org/10.1186/s10020-024-00800-3

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