Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies

Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies

This study reveals that high-copy satellite II (HSATII) sequences in the human genome can bind and impact distribution of chromatin regulatory proteins and that this goes awry in cancer. In many cancers, master regulatory proteins form two types of cancer-specific nuclear bodies, caused by locus-spe...

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Bibliographic Details
Main Authors: Lisa L. Hall, Meg Byron, Dawn M. Carone, Troy W. Whitfield, Gayle P. Pouliot, Andrew Fischer, Peter Jones, Jeanne B. Lawrence
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
cancer epigenetics
satellite heterochromatin
centromere
polycomb proteins
nuclear structure
DNA methylation
breast cancer
cancer biomarkers
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302905

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http://www.sciencedirect.com/science/article/pii/S2211124717302905

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