Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2

Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2

Gout is a common inflammatory disease. The activation of NLRP3 inflammasome induced by monosodium urate (MSU) crystals has a critical role in gout, and its prevention is beneficial for patients. Lipoxin A4 (LXA4) is an endogenous lipoxygenase-derived eicosanoid mediator with powerful anti-inflammato...

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Bibliographic Details
Main Authors: You Zhou, Yongjun Chen, Xiaowu Zhong, Hongtao Xia, Mingcai Zhao, Mengyuan Zhao, Lei Xu, Xiaolan Guo, Chong-Ge You
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
lipoxinA4
MSU
gout
NLRP3 inflammasome
ROS
Nrf2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1060441/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1060441/full

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