Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma

Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma

Acral melanoma affects the soles of the feet but the etiology is unknown. Here, the authors show that melanoma cells implanted into the foot pad of mice and exposed to mechanical stress show features of nuclear rupture, DNA damage, and Yap activation.

Bibliographic Details
Main Authors: Jimyung Seo, HyunSeok Kim, Kyoung Il Min, Changgon Kim, Yongsoo Kwon, Zhenlong Zheng, Yusung Kim, Hyung-Soon Park, Young Seok Ju, Mi Ryung Roh, Kee Yang Chung, Joon Kim
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29925-x

Internet

https://doi.org/10.1038/s41467-022-29925-x

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