Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma
Acral melanoma affects the soles of the feet but the etiology is unknown. Here, the authors show that melanoma cells implanted into the foot pad of mice and exposed to mechanical stress show features of nuclear rupture, DNA damage, and Yap activation.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29925-x |
| _version_ | 1818012332867977216 |
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| author | Jimyung Seo HyunSeok Kim Kyoung Il Min Changgon Kim Yongsoo Kwon Zhenlong Zheng Yusung Kim Hyung-Soon Park Young Seok Ju Mi Ryung Roh Kee Yang Chung Joon Kim |
| author_facet | Jimyung Seo HyunSeok Kim Kyoung Il Min Changgon Kim Yongsoo Kwon Zhenlong Zheng Yusung Kim Hyung-Soon Park Young Seok Ju Mi Ryung Roh Kee Yang Chung Joon Kim |
| author_sort | Jimyung Seo |
| collection | DOAJ |
| description | Acral melanoma affects the soles of the feet but the etiology is unknown. Here, the authors show that melanoma cells implanted into the foot pad of mice and exposed to mechanical stress show features of nuclear rupture, DNA damage, and Yap activation. |
| first_indexed | 2024-04-14T06:18:55Z |
| format | Article |
| id | doaj.art-87601f1f43a54adea5e3790c852dc173 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-14T06:18:55Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-87601f1f43a54adea5e3790c852dc1732022-12-22T02:08:06ZengNature PortfolioNature Communications2041-17232022-04-0113111510.1038/s41467-022-29925-xWeight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanomaJimyung Seo0HyunSeok Kim1Kyoung Il Min2Changgon Kim3Yongsoo Kwon4Zhenlong Zheng5Yusung Kim6Hyung-Soon Park7Young Seok Ju8Mi Ryung Roh9Kee Yang Chung10Joon Kim11Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of MedicineDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST)Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST)Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of MedicineDepartment of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of MedicineGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)Acral melanoma affects the soles of the feet but the etiology is unknown. Here, the authors show that melanoma cells implanted into the foot pad of mice and exposed to mechanical stress show features of nuclear rupture, DNA damage, and Yap activation.https://doi.org/10.1038/s41467-022-29925-x |
| spellingShingle | Jimyung Seo HyunSeok Kim Kyoung Il Min Changgon Kim Yongsoo Kwon Zhenlong Zheng Yusung Kim Hyung-Soon Park Young Seok Ju Mi Ryung Roh Kee Yang Chung Joon Kim Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma Nature Communications |
| title | Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma |
| title_full | Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma |
| title_fullStr | Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma |
| title_full_unstemmed | Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma |
| title_short | Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma |
| title_sort | weight bearing activity impairs nuclear membrane and genome integrity via yap activation in plantar melanoma |
| url | https://doi.org/10.1038/s41467-022-29925-x |
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