High Throughput Small Molecule Screen for Reactivation of <i>FMR1</i> in Fragile X Syndrome Human Neural Cells

High Throughput Small Molecule Screen for Reactivation of <i>FMR1</i> in Fragile X Syndrome Human Neural Cells

Fragile X syndrome (FXS) is the most common inherited cause of autism and intellectual disability. The majority of FXS cases are caused by transcriptional repression of the <i>FMR1</i> gene due to epigenetic changes that are not recapitulated in current animal disease models. FXS patient...

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Bibliographic Details
Main Authors: Jack F. V. Hunt, Meng Li, Ryan Risgaard, Gene E. Ananiev, Scott Wildman, Fan Zhang, Tim S. Bugni, Xinyu Zhao, Anita Bhattacharyya
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
fragile X syndrome
drug screen
human pluripotent stem cells
<i>FMR1</i>
gene reactivation
small molecule
Online Access:https://www.mdpi.com/2073-4409/11/1/69

Internet

https://www.mdpi.com/2073-4409/11/1/69

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