MiR-132-3p Modulates MEKK3-Dependent NF-κB and p38/JNK Signaling Pathways to Alleviate Spinal Cord Ischemia-Reperfusion Injury by Hindering M1 Polarization of Macrophages

MiR-132-3p Modulates MEKK3-Dependent NF-κB and p38/JNK Signaling Pathways to Alleviate Spinal Cord Ischemia-Reperfusion Injury by Hindering M1 Polarization of Macrophages

Spinal cord ischemia-reperfusion (SCIR) injury is a serious complication of open surgical and endovascular aortic procedures. MicroRNA-132-3p (miR-132-3p) has been reported to be involved in the progression of various diseases, but its role in SCIR injury is unclear. Thus, we aimed in this study to...

Full description

Bibliographic Details
Main Authors: Hua Fang, Hua-Feng Li, Qin Pan, Hon-Ling Jin, Miao Yang, Ru-Rong Wang, Quan-Yun Wang, Jian-Ping Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
spinal cord ischemia-reperfusion injury
microRNA-132-3p
MEKK3
NF-κB
p38/JNK
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.570451/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.570451/full

Similar Items