MiR-132-3p Modulates MEKK3-Dependent NF-κB and p38/JNK Signaling Pathways to Alleviate Spinal Cord Ischemia-Reperfusion Injury by Hindering M1 Polarization of Macrophages

MiR-132-3p Modulates MEKK3-Dependent NF-κB and p38/JNK Signaling Pathways to Alleviate Spinal Cord Ischemia-Reperfusion Injury by Hindering M1 Polarization of Macrophages

Spinal cord ischemia-reperfusion (SCIR) injury is a serious complication of open surgical and endovascular aortic procedures. MicroRNA-132-3p (miR-132-3p) has been reported to be involved in the progression of various diseases, but its role in SCIR injury is unclear. Thus, we aimed in this study to...

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Bibliographic Details
Main Authors: Hua Fang, Hua-Feng Li, Qin Pan, Hon-Ling Jin, Miao Yang, Ru-Rong Wang, Quan-Yun Wang, Jian-Ping Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
spinal cord ischemia-reperfusion injury
microRNA-132-3p
MEKK3
NF-κB
p38/JNK
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.570451/full

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